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KMID : 0923620230230020018
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Immune Network
2023 Volume.23 No. 2 p.18 ~ p.18
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Exercise With a Novel Digital Device Increased Serum Anti-influenza Antibody Titers After Influenza Vaccination
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Choi Jun-Pyo
Ghazal Ayoub
Ham Ja-Rang
Huh Young-Min
Choi Seung-Eun
Hwang Yu-Kyoung
Noh Ji-Yun
Kim Sae-Hoon
Song Joon-Young
Kim Eu-Suk
Chang Yoon-Seok
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Abstract
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It has been reported that some exercise could enhance the anti-viral antibody titers after vaccination including influenza and coronavirus disease 2019 vaccines. We developed SAT-008, a novel digital device, consists of physical activities and activities related to the autonomic nervous system. We assessed the feasibility of SAT-008 to boost host immunity after an influenza vaccination by a randomized, open-label, and controlled study on adults administered influenza vaccines in the previous year. Among 32 participants, the SAT-008 showed a significant increase in the anti-influenza antibody titers assessed by hemagglutination-inhibition test against antigen subtype B Yamagata lineage after 4 wk of vaccination and subtype B Victoria lineage after 12 wk (p<0.05). There was no difference in the antibody titers against subtype “A.” The SAT-008 also showed significant increase in the plasma cytokine levels of IL-10, IL-1β, and IL-6 at weeks 4 and 12 after the vaccination (p<0.05). A new approach using the digital device may boost host immunity against virus via vaccine adjuvant-like effects.
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KEYWORD
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Digital device, Vaccine, Exercise
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